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Genomics and phenomics of body mass index reveals a complex disease network.

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第一作者: Jie,Huang
第一单位: School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong, China.
作者单位: School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong, China. [1] Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. [2] Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.;Atlanta VA Health Care System, Decatur, GA, USA. [3] Network Science Institute and Department of Physics, Northeastern University, Boston, MA, USA.;Division of Population Health and Data Science, MAVERIC, VA Boston Healthcare System, Boston, MA, USA. [4] VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. [5] VA Eastern Colorado Healthcare System, Aurora, CO, USA.;University of Colorado School of Medicine, Aurora, CO, USA. [6] Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.;Institute of Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [7] Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA. [8] Network Science Institute and Department of Physics, Northeastern University, Boston, MA, USA.;Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Department of Network and Data Science, Central European University, Budapest, Hungary. [9] Carle Illinois College of Medicine, Champaign, IL, USA.;Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. [10] Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. [11] Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.;Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. [12] VA Salt Lake City Healthcare, Salt Lake City, UT, USA.;University of Massachusetts, Boston, MA, USA. [13] Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Medicine; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [14] VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. [15] Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Surgery; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [16] Phoenix VA Health Care System, Phoenix, AZ, USA.;College of Medicine, University of Arizona, Phoenix, AZ, USA. [17] Center for Healthcare Organization and Implementation Research, Bedford VA Medical Center, Bedford, MA, USA. [18] Atlanta VA Health Care System, Decatur, GA, USA.;Division of Endocrinology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. [19] Vanderbilt Genetics Institute and Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. [20] Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA. [21] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. [22] The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [23] Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. [24] Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.;Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. [25] Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan.;Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.;Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA. [26] Department of Medicine; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [27] Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.;Atlanta VA Health Care System, Decatur, GA, USA.;Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA. [28] Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA. yan.v.sun@emory.edu.;Atlanta VA Health Care System, Decatur, GA, USA. yan.v.sun@emory.edu. [29] Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. christopher.odonnell@va.gov.;Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. christopher.odonnell@va.gov.;Cardiology Section, VA Boston Healthcare System, Boston, MA, USA. christopher.odonnell@va.gov. [30]
DOI 10.1038/s41467-022-35553-2
PMID 36581621
发布时间 2024-12-05
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