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Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer.

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第一作者： Ruth M,Escalona

第一单位： Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, 3052, Australia.;Centre for Reproductive Health, Hudson Institute of Medical Research and Department of Translational Medicine, Monash University, Clayton, VIC, 3168, Australia.;Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia.

作者： Ruth M,Escalona ^[1] ; Simon,Chu ^[2] ; Elif,Kadife ^[3] ; Jason K,Kelly ^[3] ; George,Kannourakis ^[4] ; Jock K,Findlay ^[5] ; Nuzhat,Ahmed ^[6]

作者单位： Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, 3052, Australia.;Centre for Reproductive Health, Hudson Institute of Medical Research and Department of Translational Medicine, Monash University, Clayton, VIC, 3168, Australia.;Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia. ^[1] Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and Department of Translational Medicine, Monash University, Clayton, VIC, 3168, Australia. ^[2] Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia. ^[3] Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia.;School of Science, Psychology and Sport, Federation University, Mt Helen, VIC, 3350, Australia. ^[4] Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, 3052, Australia.;Centre for Reproductive Health, Hudson Institute of Medical Research and Department of Translational Medicine, Monash University, Clayton, VIC, 3168, Australia. ^[5] Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, 3052, Australia. nuzhata@unimelb.edu.au.;Centre for Reproductive Health, Hudson Institute of Medical Research and Department of Translational Medicine, Monash University, Clayton, VIC, 3168, Australia. nuzhata@unimelb.edu.au.;Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia. nuzhata@unimelb.edu.au.;School of Science, Psychology and Sport, Federation University, Mt Helen, VIC, 3350, Australia. nuzhata@unimelb.edu.au. ^[6]

关键词 CRISPR/Cas-9 Invasion MMP14 MMP2 Migration Ovarian cancer Proliferation TIMP-2 siRNA

DOI 10.1186/s12935-022-02838-x

PMID 36585738

发布时间 2023-01-11

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