Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer.

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作者： Tsehai A J,Grell ^[1] ; Mark,Mason ^[1] ; Aaron A,Thompson ^[2] ; Jose Carlos,Gómez-Tamayo ^[3] ; Daniel,Riley ^[4] ; Michelle V,Wagner ^[5] ; Ruth,Steele ^[1] ; Rodrigo F,Ortiz-Meoz ^[4] ; Jay,Wadia ^[5] ; Paul L,Shaffer ^[1] ; Gary,Tresadern ^[3] ; Sujata,Sharma ^[1] ; Xiaodi,Yu ^[2]

作者单位： Structural and Protein Sciences, Janssen Research and Development, LLC, Spring House, Pennsylvania 19477, United States. ^[1] Structural and Protein Sciences, Janssen Research and Development, LLC, San Diego, California 92121, United States. ^[2] Computational Chemistry, Janssen Research and Development, LLC, Beerse, B2340, Belgium. ^[3] Lead Discovery and Molecular Pharmacology, Janssen Research and Development, LLC, Spring House, Pennsylvania 19477, United States. ^[4] Emerging Science Initiative, Janssen Research and Development, LLC, San Diego, California 92121, United States. ^[5]

关键词 Allostery Drug discovery Malic enzymes Single particle Cryo-EM X-ray crystallography

DOI 10.1016/j.heliyon.2022.e12392

PMID 36590518

发布时间 2023-01-03

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Heliyon

2022年8卷12期

e12392页

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Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer.

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Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer.

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