Incorporation of a recirculating mobile lipid pool description into the cyclic volatile siloxane (cVMS) PBPK model captures terminal clearance of D<sub>4</sub> after repeated inhalation exposure in F344 and SD Rats.
作者:
主题词
大鼠(Rats);男(雄)性(Male);女(雌)性(Female);人类(Humans);动物(Animals);大鼠, 近交F344(Rats, Inbred F344);吸入暴露(Inhalation Exposure);硅氧烷类(Siloxanes);动力学(Kinetics);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);模型, 生物学(Models, Biological);脂类(Lipids)
DOI
10.1016/j.toxlet.2022.12.014
PMID
36596351
发布时间
2023-02-02
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Toxicology letters
29-38页
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