Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria.

导出 OA

翻译打印收藏纠错

第一作者： Adama,Gansane

第一单位： Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 220801 BP 2208, Ouagadougou, Burkina Faso. agansane.cnrfp@fasonet.bf.

作者： Adama,Gansane ^[1] ; Moussa,Lingani ^[2] ; Adoke,Yeka ^[3] ; Alain,Nahum ^[4] ; Marielle,Bouyou-Akotet ^[5] ; Ghyslain,Mombo-Ngoma ^[6] ; Grace,Kaguthi ^[7] ; Catalina,Barceló ^[8] ; Bart,Laurijssens ^[9] ; Cathy,Cantalloube ^[10] ; Fiona,Macintyre ^[11] ; Elhadj,Djeriou ^[12] ; Andreas,Jessel ^[10] ; Raphaël,Bejuit ^[12] ; Helen,Demarest ^[13] ; Anne Claire,Marrast ^[12] ; Siaka,Debe ^[10] ; Halidou,Tinto ^[10] ; Afizi,Kibuuka ^[14] ; Diolinda,Nahum ^[2] ; Denise Patricia,Mawili-Mboumba ^[3] ; Rella,Zoleko-Manego ^[4] ; Irene,Mugenya ^[5] ; Frederick,Olewe ^[6] ; Stephan,Duparc ^[7] ; Bernhards,Ogutu ^[8]

作者单位： Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 220801 BP 2208, Ouagadougou, Burkina Faso. agansane.cnrfp@fasonet.bf. ^[1] Institut de Recherche en Science de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Ouagadougou, Burkina Faso. ^[2] Infectious Diseases Research Collaboration (IDRC), Kampala, Uganda. ^[3] Centre de Recherches Entomologique de Cotonou (CREC), Cotonou, Benin. ^[4] Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine - Université des Sciences de la Santé, Libreville, Gabon. ^[5] Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon. ^[6] Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[7] Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany. ^[8] Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), Nairobi, Kenya. ^[9] Medicines for Malaria Venture, Geneva, Switzerland. ^[10] BEL Pharm Consulting, Chambonas, France. ^[11] Sanofi Research and Development, Chilly Mazarin, France. ^[12] Sanofi Research and Development, Bridgewater, NJ, USA. ^[13] Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 220801 BP 2208, Ouagadougou, Burkina Faso. ^[14] Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya. ^[15] Centre for Research in Therapeutic Sciences (CREATES), Strathmore University, Nairobi, Kenya. ^[16]

关键词 Artefenomel Clinical trial Combination treatment Exposure–response Ferroquine Uncomplicated P. falciparum malaria

主题词人类(Humans);抗疟药(Antimalarials);恶性疟原虫(Plasmodium falciparum);疟疾, 恶性(Malaria, Falciparum);氨基喹啉类(Aminoquinolines);治疗结果(Treatment Outcome);复方合剂(Drug Combinations)

DOI 10.1186/s12936-022-04420-2

PMID 36597076

发布时间 2023-01-11

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交