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CD8<sup>+</sup> T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.

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第一作者： Mahrukh A,Huseni

第一单位： Genentech, South San Francisco, CA 94080, USA. Electronic address: huseni.mahrukh@gene.com.

作者： Mahrukh A,Huseni ^[1] ; Lifen,Wang ^[2] ; Joanna E,Klementowicz ^[2] ; Kobe,Yuen ^[2] ; Beatrice,Breart ^[2] ; Christine,Orr ^[2] ; Li-Fen,Liu ^[2] ; Yijin,Li ^[2] ; Vinita,Gupta ^[2] ; Congfen,Li ^[2] ; Deepali,Rishipathak ^[2] ; Jing,Peng ^[2] ; Yasin,Şenbabaoǧlu ^[2] ; Zora,Modrusan ^[2] ; Shilpa,Keerthivasan ^[2] ; Shravan,Madireddi ^[2] ; Ying-Jiun,Chen ^[2] ; Eleanor J,Fraser ^[2] ; Ning,Leng ^[2] ; Habib,Hamidi ^[2] ; Hartmut,Koeppen ^[2] ; James,Ziai ^[2] ; Kenji,Hashimoto ^[2] ; Marcella,Fassò ^[2] ; Patrick,Williams ^[2] ; David F,McDermott ^[3] ; Jonathan E,Rosenberg ^[4] ; Thomas,Powles ^[5] ; Leisha A,Emens ^[6] ; Priti S,Hegde ^[2] ; Ira,Mellman ^[2] ; Shannon J,Turley ^[2] ; Mark S,Wilson ^[2] ; Sanjeev,Mariathasan ^[2] ; Luciana,Molinero ^[2] ; Mark,Merchant ^[2] ; Nathaniel R,West ^[7]

作者单位： Genentech, South San Francisco, CA 94080, USA. Electronic address: huseni.mahrukh@gene.com. ^[1] Genentech, South San Francisco, CA 94080, USA. ^[2] Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. ^[3] Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[4] Barts Experimental Cancer Medicine Centre, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK. ^[5] University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15213, USA. ^[6] Genentech, South San Francisco, CA 94080, USA. Electronic address: west.nathaniel@gene.com. ^[7]

关键词 CD8 T?cell IL-6 PD-L1 atezolizumab cancer checkpoint blockade immunotherapy clinical trial interleukin 6

医学主题词动物(Animals);小鼠(Mice);抗肿瘤药(Antineoplastic Agents);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);免疫疗法(Immunotherapy);白细胞介素6(Interleukin-6);肿瘤(Neoplasms)

DOI 10.1016/j.xcrm.2022.100878

PMID 36599350

发布时间 2023-03-15

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