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Synthesis and biological evaluation of tert-butyl ester and ethyl ester prodrugs of L-γ-methyleneglutamic acid amides for cancer.

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作者单位: Department of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA. [1] Cancer Center & Research Institute, Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA. [2] Natural Products Utilization Research Unit, United States Department of Agriculture, Agricultural Research Service, University, MS 38677, USA. [3] Center of Biomedical Research Excellence (COBRE) CDMPK Core, School of Pharmacy, University of Mississippi, University, MS 38677, USA. [4] Department of Pharmaceutics and Drug Delivery and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA. [5] Department of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA; Cancer Center & Research Institute, Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA. [6] Department of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA. Electronic address: hle@olemiss.edu. [7]
DOI 10.1016/j.bmc.2022.117137
PMID 36603398
发布时间 2024-01-16
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