Targeting mitochondrial impairment for the treatment of cardiovascular diseases: From hypertension to ischemia-reperfusion injury, searching for new pharmacological targets.
第一作者:
Simona,Todisco
第一单位:
Department of Sciences, University of Basilicata, Viale dell'Ateneo Lucano, 10‑85100 Potenza, Italy.
作者:
关键词
AquaporinCardiolipinCardiovascular diseasesDrug-RepurposingGenomicsHypertensionIschemia reperfusion injuryMetabolomicsMitochondrial carriersMitochondrial diseasesMitochondrial dynamicsMitochondrial dysfunctionMitochondrial impairmentMitochondrial metabolite transport systemMitochondrial permeability transition poreMitochondrial pharmacological targetsMitochondrial pyruvate carrierMitochondrial targets for CVD treatmentsMolecular modeling of mitochondrial proteinsRespiratory chainTranscriptomicsVoltage-dependent anion channels
主题词
人类(Humans);心血管疾病(Cardiovascular Diseases);苹果酸盐(Malates);天冬氨酸(Aspartic Acid);线粒体(Mitochondria);线粒体膜转运蛋白质类(Mitochondrial Membrane Transport Proteins);高血压(Hypertension);线粒体蛋白质类(Mitochondrial Proteins);再灌注损伤(Reperfusion Injury);腺苷三磷酸(Adenosine Triphosphate)
DOI
10.1016/j.bcp.2022.115405
PMID
36603686
发布时间
2023-02-07
- 浏览3
Biochemical pharmacology
115405页
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