Double and quadruple deletion mutant of EHV-1 is highly attenuated and induces optimal immune response.

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作者： Venkataramireddy,Balena ^[1] ; Stephanie S,Pradhan ^[1] ; B C,Bera ^[2] ; Taruna,Anand ^[2] ; Rekha,Sansanwal ^[2] ; Rhushikesh,Khetmalis ^[1] ; Aashwina,Madhwal ^[1] ; Manju,Bernela ^[2] ; K,Supriya ^[1] ; S,Pavulraj ^[3] ; B N,Tripathi ^[4] ; Nitin,Virmani ^[5]

作者单位： ICAR-National Research Centre on Equines, Sirsa Road, Hisar 125 001, Haryana, India; Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly 243122, UP, India. ^[1] ICAR-National Research Centre on Equines, Sirsa Road, Hisar 125 001, Haryana, India. ^[2] Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. ^[3] Indian Council of Agricultural Research, Krishi Bhawan, New Delhi 110012, India. Electronic address: bntripathi1@yahoo.com. ^[4] ICAR-National Research Centre on Equines, Sirsa Road, Hisar 125 001, Haryana, India. Electronic address: nvirmani@gmail.com. ^[5]

关键词 Bacterial artificial chromosome EHV-1 Equid alphaherpesvirus 1 Equine Immune response Modified live vaccine Murine model Mutagenesis Pathogenesis