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An exosome-based liquid biopsy signature for pre-operative identification of lymph node metastasis in patients with pathological high-risk T1 colorectal cancer.

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第一作者： Katsuki,Miyazaki

第一单位： Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, 1218 S. Fifth Avenue, Suite 2226, Monrovia, CA, 91016, USA.;Department of Surgery, Tokushima University, Tokushima, Japan.

作者： Katsuki,Miyazaki ^[1] ; Yuma,Wada ^[1] ; Keisuke,Okuno ^[2] ; Tatsuro,Murano ^[3] ; Yuji,Morine ^[4] ; Tetsuya,Ikemoto ^[4] ; Yu,Saito ^[4] ; Hiroaki,Ikematsu ^[3] ; Yusuke,Kinugasa ^[5] ; Mitsuo,Shimada ^[4] ; Ajay,Goel ^[6]

作者单位： Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, 1218 S. Fifth Avenue, Suite 2226, Monrovia, CA, 91016, USA.;Department of Surgery, Tokushima University, Tokushima, Japan. ^[1] Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, 1218 S. Fifth Avenue, Suite 2226, Monrovia, CA, 91016, USA.;Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan. ^[2] Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan. ^[3] Department of Surgery, Tokushima University, Tokushima, Japan. ^[4] Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan. ^[5] Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, 1218 S. Fifth Avenue, Suite 2226, Monrovia, CA, 91016, USA. ajgoel@coh.org.;City of Hope Comprehensive Cancer Center, Duarte, CA, USA. ajgoel@coh.org. ^[6]

关键词 Cell-free miRNA Exosomal miRNA Liquid biopsy Lymph node metastasis T1 CRC

医学主题词人类(Humans);淋巴转移(Lymphatic Metastasis);外泌体(Exosomes);结直肠肿瘤(Colorectal Neoplasms);微RNAs(MicroRNAs)

DOI 10.1186/s12943-022-01685-8

PMID 36609320

发布时间 2023-02-02

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