Evolutionary Analysis of TCGA Data Using Over- and Under- Mutated Genes Identify Key Molecular Pathways and Cellular Functions in Lung Cancer Subtypes.

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作者： Audrey R,Freischel ^[1] ; Jamie K,Teer ^[2] ; Kimberly,Luddy ^[2] ; Jessica,Cunningham ^[3] ; Yael,Artzy-Randrup ^[1] ; Tamir,Epstein ^[4] ; Kenneth Y,Tsai ^[1] ; Anders,Berglund ^[5] ; John L,Cleveland ^[1] ; Robert J,Gillies ^[3] ; Joel S,Brown ^[5] ; Robert A,Gatenby ^[3]

作者单位： Departments of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. ^[1] Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. ^[2] Departments of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. ^[3] Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. ^[4] Departments of Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. ^[5] Departments of Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. ^[6] Department of Diagnostic Imaging & Interventional Radiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. ^[7]

关键词 EGFR KRAS cancer cell fitness cancer genetics evolutionary triage lung cancer

DOI 10.3390/cancers15010018

PMID 36612014

发布时间 2024-01-21

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