Inhibition of <i>Leishmania infantum</i> Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site.

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作者： Valentina Noemi,Madia ^[1] ; Davide,Ialongo ^[1] ; Elisa,Patacchini ^[1] ; Cécile,Exertier ^[2] ; Lorenzo,Antonelli ^[2] ; Gianni,Colotti ^[3] ; Antonella,Messore ^[2] ; Valeria,Tudino ^[1] ; Francesco,Saccoliti ^[1] ; Luigi,Scipione ^[4] ; Andrea,Ilari ^[1] ; Roberta,Costi ^[2] ; Roberto,Di Santo ^[1]

作者单位： Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, "Sapienza" Università di Roma, p.le Aldo Moro 5, 00185 Rome, Italy. ^[1] Istituto di Biologia e Patologia Molecolari del CNR c/o Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, p.le Aldo Moro 5, 00185 Roma, Italy. ^[2] Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, p.le Aldo Moro 5, 00185 Roma, Italy. ^[3] D3 PharmaChemistry, Italian Institute of Technology, Via Morego 30, 16163 Genova, Italy. ^[4]

关键词 Leishmania infantum NADPH binding site X-ray crystal structure cluster docking procainamide derivatives procaine derivatives trypanothione reductase inhibition

主题词人类(Humans);婴儿利什曼原虫(Leishmania infantum);NADP(NADP);模型, 分子(Models, Molecular);NADH, NADPH氧化还原酶类(NADH, NADPH Oxidoreductases);结合部位(Binding Sites);抗原虫药(Antiprotozoal Agents)

DOI 10.3390/molecules28010338

PMID 36615531

发布时间 2023-01-11

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