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Returning integrated genomic risk and clinical recommendations: The eMERGE study.

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第一作者: Jodell E,Linder
第一单位: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN.
作者: Jodell E,Linder [1] ; Aimee,Allworth [2] ; Harris T,Bland [3] ; Pedro J,Caraballo [4] ; Rex L,Chisholm [5] ; Ellen Wright,Clayton [6] ; David R,Crosslin [7] ; Ozan,Dikilitas [8] ; Alanna,DiVietro [1] ; Edward D,Esplin [9] ; Sophie,Forman [1] ; Robert R,Freimuth [10] ; Adam S,Gordon [11] ; Richard,Green [12] ; Maegan V,Harden [13] ; Ingrid A,Holm [14] ; Gail P,Jarvik [15] ; Elizabeth W,Karlson [16] ; Sofia,Labrecque [1] ; Niall J,Lennon [13] ; Nita A,Limdi [17] ; Kathleen F,Mittendorf [18] ; Shawn N,Murphy [19] ; Lori,Orlando [20] ; Cynthia A,Prows [21] ; Luke V,Rasmussen [22] ; Laura,Rasmussen-Torvik [22] ; Robb,Rowley [23] ; Konrad Teodor,Sawicki [24] ; Tara,Schmidlen [9] ; Shannon,Terek [25] ; David,Veenstra [26] ; Digna R,Velez Edwards [27] ; Devin,Absher [28] ; Noura S,Abul-Husn [29] ; Jorge,Alsip [30] ; Hana,Bangash [31] ; Mark,Beasley [32] ; Jennifer E,Below [33] ; Eta S,Berner [34] ; James,Booth [35] ; Wendy K,Chung [36] ; James J,Cimino [37] ; John,Connolly [25] ; Patrick,Davis [12] ; Beth,Devine [26] ; Stephanie M,Fullerton [38] ; Candace,Guiducci [13] ; Melissa L,Habrat [12] ; Heather,Hain [25] ; Hakon,Hakonarson [25] ; Margaret,Harr [25] ; Eden,Haverfield [9] ; Valentina,Hernandez [39] ; Christin,Hoell [40] ; Martha,Horike-Pyne [2] ; George,Hripcsak [41] ; Marguerite R,Irvin [42] ; Christopher,Kachulis [13] ; Dean,Karavite [43] ; Eimear E,Kenny [29] ; Atlas,Khan [44] ; Krzysztof,Kiryluk [44] ; Bruce,Korf [45] ; Leah,Kottyan [46] ; Iftikhar J,Kullo [31] ; Katie,Larkin [13] ; Cong,Liu [41] ; Edyta,Malolepsza [13] ; Teri A,Manolio [23] ; Thomas,May [47] ; Elizabeth M,McNally [5] ; Frank,Mentch [25] ; Alexandra,Miller [31] ; Sean D,Mooney [12] ; Priyanka,Murali [2] ; Brenda,Mutai [2] ; Naveen,Muthu [43] ; Bahram,Namjou [46] ; Emma F,Perez [48] ; Megan J,Puckelwartz [11] ; Tejinder,Rakhra-Burris [20] ; Dan M,Roden [49] ; Elisabeth A,Rosenthal [2] ; Seyedmohammad,Saadatagah [31] ; Maya,Sabatello [50] ; Dan J,Schaid [51] ; Baergen,Schultz [23] ; Lynn,Seabolt [1] ; Gabriel Q,Shaibi [52] ; Richard R,Sharp [53] ; Brian,Shirts [54] ; Maureen E,Smith [24] ; Jordan W,Smoller [55] ; Rene,Sterling [56] ; Sabrina A,Suckiel [57] ; Jeritt,Thayer [43] ; Hemant K,Tiwari [32] ; Susan B,Trinidad [38] ; Theresa,Walunas [58] ; Wei-Qi,Wei [3] ; Quinn S,Wells [59] ; Chunhua,Weng [41] ; Georgia L,Wiesner [33] ; Ken,Wiley [23] ; eMERGE Consortium [60] ; Josh F,Peterson
作者单位: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN. [1] Division of Medical Genetics, Department of Medicine, University of Washington Medical Center, Seattle, WA. [2] Department of Biomedical Informatics and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. [3] Department of Internal Medicine and Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN. [4] Center for Genetic Medicine, Northwestern University, Chicago, IL. [5] Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, TN. [6] Division of Biomedical Informatics and Genomics, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA. [7] Mayo Clinician Investigator Training Program, Department of Internal Medicine and Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. [8] Invitae, San Francisco, CA. [9] Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN. [10] Department of Pharmacology, Feinberg School of Medicine, and Center for Genetic Medicine, Northwestern University, Chicago, IL. [11] Department of Biomedical Informatics and Medical Education, University of Washington Medical Center, Seattle, WA. [12] Broad Institute of MIT and Harvard, Cambridge, MA. [13] Division of Genetics and Genomics and Manton Center for Orphan Diseases Research, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA. [14] Division of Medical Genetics, Department of Medicine and Department of Genome Science, University of Washington Medical Center, Seattle, WA. [15] Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA. [16] Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL. [17] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN. [18] Department of Neurology, Massachusetts General Hospital, Boston, MA. [19] Center for Applied Genomics and Precision Medicine, Duke University, Durham, NC. [20] Divisions of Human Genetics and Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. [21] Department of Preventive Medicine, Northwestern University, Chicago, IL. [22] Division of Genomic Medicine, National Human Genome Research Institute, Bethesda, MD. [23] Department of Cardiology and Center for Genetic Medicine, Northwestern University, Chicago, IL. [24] Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA. [25] School of Pharmacy, University of Washington, Seattle, WA. [26] Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Vanderbilt University Medical Center, Nashville, TN. [27] Kaiser Permanente Research Bank, Oakland, CA. [28] Institute for Genomic Health, Department of Medicine, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY. [29] UAB Medicine Enterprise, Birmingham, AL. [30] Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. [31] Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL. [32] Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN. [33] Department of Health Services Administration, University of Alabama at Birmingham, Birmingham, AL. [34] Department of Emergency Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL. [35] Departments of Pediatrics and Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY. [36] Division of General Internal Medicine and the Informatics Institute, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL. [37] Department of Bioethics and Humanities, University of Washington School of Medicine, Seattle, WA. [38] Mountain Park Health Center, Phoenix, AZ. [39] Department of Obstetrics & Gynecology and Center for Genetic Medicine, Northwestern University, Chicago, IL. [40] Department of Biomedical Informatics, Columbia University Irving Medical Center, Columbia University, New York, NY. [41] Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL. [42] Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA. [43] Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, NY. [44] Department of Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL. [45] The Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. [46] Elson S. Floyd College of Medicine, Washington State University, Vancouver, WA. [47] Department of Medicine, Brigham and Women's Hospital, Mass General Brigham Personalized Medicine, Boston, MA. [48] Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN. [49] Division of Nephrology, Department of Medicine & Division of Ethics, Department of Medical Humanities and Ethics, Columbia University Irving Medical Center, New York, NY. [50] Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN. [51] Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, AZ. [52] Biomedical Ethics Program, Department of Quantitative Health Science, Mayo Clinic, Rochester, MN. [53] Department of Laboratory Medicine & Pathology, University of Washington Medical Center, Seattle, WA. [54] Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA. [55] Division of Genomics and Society, National Human Genome Research Institute, Bethesda, MD. [56] The Institute for Genomic Health, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. [57] Department of Medicine and Center for Health Information Partnerships, Northwestern University, Chicago, IL. [58] Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN. [59] Center for Precision Medicine, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN. Electronic address: josh.peterson@vumc.org. [60]
DOI 10.1016/j.gim.2023.100006
PMID 36621880
发布时间 2026-04-08
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Genetics in medicine : official journal of the American College of Medical Genetics

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