Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion.

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作者： Alicia,Wong ^[1] ; Samantha,Pritchard ^[2] ; Mackenzie,Moore ^[2] ; Brian,Akhaphong ^[2] ; Nandini,Avula ^[2] ; Megan,Beetch ^[2] ; Yoshio,Fujitani ^[3] ; Emilyn U,Alejandro ^[4]

作者单位： Department of Integrative Biology & Physiology, University of Minnesota, Minneapolis, Minnesota, USA; Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, Minnesota, USA. ^[1] Department of Integrative Biology & Physiology, University of Minnesota, Minneapolis, Minnesota, USA. ^[2] Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan. ^[3] Department of Integrative Biology & Physiology, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: ealejand@umn.edu. ^[4]

关键词 CHOP ER stress O-GlcNAc transferase O-GlcNAcylation Pdx1 beta-cell islet p53 pancreas development transcription factors

主题词动物(Animals);小鼠(Mice);胰高血糖素分泌细胞(Glucagon-Secreting Cells);胰腺, 外分泌部(Pancreas, Exocrine);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);基因表达(Gene Expression);胰腺疾病(Pancreatic Diseases)

DOI 10.1016/j.jbc.2023.102878

PMID 36623733

发布时间 2023-12-20

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