Supercritical fluid coating of flavonoids on excipients enhances drug release and antioxidant activity.

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作者： Hongling,He ^[1] ; Yating,Huang ^[1] ; Xiubing,Zhang ^[2] ; Yanting,Ouyang ^[3] ; Piaopiao,Pan ^[4] ; Yanling,Lan ^[1] ; Zicheng,Zhong ^[1] ; Lu,Ping ^[2] ; Tiejun,Lu ^[5] ; Zhenqiu,Chen ^[6] ; Lei,Xing ^[7] ; Qingguo,Li ^[8] ; Zhenwen,Qiu ^[9]

作者单位： School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. ^[1] The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. ^[2] Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan 528329, Guangdong, PR China. ^[3] Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8QQ, UK. ^[4] Centre for Formulation Engineering, School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK. ^[5] The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. Electronic address: chenzhenqiu2012@126.com. ^[6] Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK. Electronic address: l.xing@surrey.ac.uk. ^[7] School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address: lqg8512@gzucm.edu.cn. ^[8] The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. Electronic address: qzhenwen@gzucm.edu.cn. ^[9]

关键词 Dihydromyricetin Flavonoids Luteolin Naringenin Supercritical anti-solvent fluidized bed

主题词抗氧化剂(Antioxidants);辅药(Excipients);类黄酮物质(Flavonoids);溶剂(Solvents);粒子大小(Particle Size);溶解度(Solubility);显微镜检查, 电子, 扫描(Microscopy, Electron, Scanning)

DOI 10.1016/j.ijpharm.2023.122593

PMID 36626970

发布时间 2023-03-13

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准确一般字义偏差语意偏离译文作用小提交