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A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies.

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第一作者： Frederic,Bibollet-Ruche

第一单位： Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

作者： Frederic,Bibollet-Ruche ^[1] ; Ronnie M,Russell ^[1] ; Wenge,Ding ^[1] ; Weimin,Liu ^[1] ; Yingying,Li ^[1] ; Kshitij,Wagh ^[2] ; Daniel,Wrapp ^[3] ; Rumi,Habib ^[4] ; Ashwin N,Skelly ^[4] ; Ryan S,Roark ^[1] ; Scott,Sherrill-Mix ^[1] ; Shuyi,Wang ^[1] ; Juliette,Rando ^[1] ; Emily,Lindemuth ^[1] ; Kendra,Cruickshank ^[1] ; Younghoon,Park ^[1] ; Rachel,Baum ^[1] ; John W,Carey ^[1] ; Andrew Jesse,Connell ^[1] ; Hui,Li ^[1] ; Elena E,Giorgi ^[2] ; Ge S,Song ^[5] ; Shilei,Ding ^[6] ; Andrés,Finzi ^[6] ; Amanda,Newman ^[3] ; Giovanna E,Hernandez ^[3] ; Emily,Machiele ^[3] ; Derek W,Cain ^[3] ; Katayoun,Mansouri ^[7] ; Mark G,Lewis ^[8] ; David C,Montefiori ^[9] ; Kevin J,Wiehe ^[3] ; S Munir,Alam ^[3] ; I-Ting,Teng ^[10] ; Peter D,Kwong ^[10] ; Raiees,Andrabi ^[5] ; Laurent,Verkoczy ^[11] ; Dennis R,Burton ^[12] ; Bette T,Korber ^[2] ; Kevin O,Saunders ^[3] ; Barton F,Haynes ^[3] ; Robert J,Edwards ^[3] ; George M,Shaw ^[1] ; Beatrice H,Hahn ^[1]

作者单位： Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[1] Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA. ^[2] Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.;Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA. ^[3] Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, USA.;Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[4] Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA. ^[5] Centre de Recherche du CHUM, Montreal, Quebec, Canada.;Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada. ^[6] Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA. ^[7] Bioqual, Inc., Rockville, Maryland, USA. ^[8] Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA. ^[9] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[10] San Diego Biomedical Research Institute, San Diego, California, USA. ^[11] Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA.;Ragon Institute of MGH, Harvard and MIT, Cambridge, Massachusetts, USA. ^[12]

关键词 SCIV V2-apex broadly neutralizing antibodies chimpanzee germline-targeting human immunodeficiency virus immunofocusing neutralizing antibodies occluded-open trimer vaccines