Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.

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作者： Jina,Yun ^[1] ; Simon,Hansen ^[2] ; Otto,Morris ^[3] ; David T,Madden ^[4] ; Clare Peters,Libeu ^[4] ; Arjun J,Kumar ^[5] ; Cameron,Wehrfritz ^[4] ; Aaron H,Nile ^[6] ; Yingnan,Zhang ^[1] ; Lijuan,Zhou ^[1] ; Yuxin,Liang ^[1] ; Zora,Modrusan ^[1] ; Michelle B,Chen ^[1] ; Christopher C,Overall ^[1] ; David,Garfield ^[1] ; Judith,Campisi ^[4] ; Birgit,Schilling ^[4] ; Rami N,Hannoush ^[7] ; Heinrich,Jasper ^[8]

作者单位： Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. ^[1] NBE Therapeutics, Hochbergstrasse 60C, 4057, Basel, Switzerland. ^[2] Exscientia Ltd., The Schrödinger Building Oxford Science Park, Oxford, OX4 4GE, UK. ^[3] Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA. ^[4] Fred Hutch/University of Washington, 1100 Fairview Ave. N., Seattle, WA, 98109, USA. ^[5] Calico Labs LLC., 1170 Veterans Blvd, South San Francisco, CA, 94080, USA. ^[6] Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. ramih@gene.com. ^[7] Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. jasperh@gene.com. ^[8] Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA. jasperh@gene.com. ^[9]