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Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.

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作者单位: German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany. [1] Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Venusberg-Campus 1, 53127, Bonn, Germany. [2] German Center for Neurodegenerative Diseases (DZNE), Leipziger Straße 44, 39120, Magdeburg, Germany. [3] Institute of Innate Immunity, University of Bonn Medical Center, Venusberg-Campus 1, 53127, Bonn, Germany. [4] Bayer AG, Alfred-Nobel-Straße 50, 40789, Monheim am Rhein, Germany. [5] Hertie Institute for Clinical Brain Research, Department Cellular Neurology, University of Tübingen, Otfried-Müller-Strasse 27, 72076, Tübingen, Germany. [6] German Center for Neurodegenerative Diseases (DZNE), Otfried-Müller-Straße 27, 72076, Tübingen, Germany. [7] Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931, Köln, Germany. [8] German Center for Neurodegenerative Diseases (DZNE), Charitéplatz 1, 10117, Berlin, Germany. [9] Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany. [10] Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany. [11] Department of Psychiatry and Psychotherapy, Technical University Munich, 81675, Munich, Germany. [12] German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany. [13] Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany. [14] Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. [15] Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118, Magdeburg, Germany. [16] German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Strasse 17, 81377, Munich, Germany. [17] Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Strasse 17, 81377, Munich, Germany. [18] Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. [19] Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany. [20] Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK. [21] Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. [22] German Center for Neurodegenerative Diseases (DZNE), Gehlsheimer Str. 20, 18147, Rostock, Germany. [23] Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany. [24] Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany. [25] Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany. [26] Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany. [27] MR-Research in Neurosciences, Department of Cognitive Neurology, Georg-August-University, Goettingen, Germany. [28] Bernstein Center for Computational Neurosciences, Charité - Universitätsmedizin, Berlin, Germany. [29] Department for Biomedical Magnetic Resonance, University of Tübingen, 72076, Tübingen, Germany. [30] Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener Strasse 62, 50924, Cologne, Germany. [31] Department of Neurology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. [32] Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. [33] Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA. [34] Division Translational Genomics of Neurodegenerative Diseases, Center for Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller-Strasse 27, 72076, Tübingen, Germany. [35] German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany. michael.heneka@uni.lu. [36] Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Venusberg-Campus 1, 53127, Bonn, Germany. michael.heneka@uni.lu. [37] Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7 avenue des Hauts Fourneaux, 4362, Esch-sur- Alzette, Luxembourg. michael.heneka@uni.lu. [38]
DOI 10.1186/s13195-022-01118-0
PMID 36631909
发布时间 2023-02-15
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