Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.
作者:
Frederic,Brosseron [1]
;
Anne,Maass [2]
;
Luca,Kleineidam [3]
;
Kishore Aravind,Ravichandran [1]
;
Carl-Christian,Kolbe [2]
;
Steffen,Wolfsgruber [1]
;
Francesco,Santarelli [2]
;
Lisa M,Häsler [4]
;
Róisín,McManus [5]
;
Christina,Ising [1]
;
Sandra,Röske [2]
;
Oliver,Peters [1]
;
Nicoleta-Carmen,Cosma [2]
;
Luisa-Sophie,Schneider [6]
;
Xiao,Wang [7]
;
Josef,Priller [1]
;
Eike J,Spruth [2]
;
Slawek,Altenstein [1]
;
Anja,Schneider [2]
;
Klaus,Fliessbach [8]
;
Jens,Wiltfang [2]
;
Björn H,Schott [9]
;
Katharina,Buerger [10]
;
Daniel,Janowitz [11]
;
Martin,Dichgans [9]
;
Robert,Perneczky [10]
;
Boris-Stephan,Rauchmann [10]
;
Stefan,Teipel [9]
;
Ingo,Kilimann [10]
;
Doreen,Görß [12]
;
Christoph,Laske [9]
;
Matthias H,Munk [10]
;
Emrah,Düzel [9]
;
Renat,Yakupow [10]
;
Laura,Dobisch [1]
;
Coraline D,Metzger [2]
;
Wenzel,Glanz [1]
;
Michael,Ewers [2]
;
Peter,Dechent [13]
;
John Dylan,Haynes [14]
;
Klaus,Scheffler [15]
;
Nina,Roy [13]
;
Ayda,Rostamzadeh [14]
;
Annika,Spottke [16]
;
Alfredo,Ramirez [17]
;
David,Mengel [18]
;
Matthis,Synofzik [18]
;
Mathias,Jucker [17]
;
Eicke,Latz [18]
;
Frank,Jessen [17]
;
Michael,Wagner [19]
;
Michael T,Heneka [20]
;
DELCODE study group [21]
作者单位:
German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany.
[1]
Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Venusberg-Campus 1, 53127, Bonn, Germany.
[2]
German Center for Neurodegenerative Diseases (DZNE), Leipziger Straße 44, 39120, Magdeburg, Germany.
[3]
Institute of Innate Immunity, University of Bonn Medical Center, Venusberg-Campus 1, 53127, Bonn, Germany.
[4]
Bayer AG, Alfred-Nobel-Straße 50, 40789, Monheim am Rhein, Germany.
[5]
Hertie Institute for Clinical Brain Research, Department Cellular Neurology, University of Tübingen, Otfried-Müller-Strasse 27, 72076, Tübingen, Germany.
[6]
German Center for Neurodegenerative Diseases (DZNE), Otfried-Müller-Straße 27, 72076, Tübingen, Germany.
[7]
Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931, Köln, Germany.
[8]
German Center for Neurodegenerative Diseases (DZNE), Charitéplatz 1, 10117, Berlin, Germany.
[9]
Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany.
[10]
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
[11]
Department of Psychiatry and Psychotherapy, Technical University Munich, 81675, Munich, Germany.
[12]
German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany.
[13]
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany.
[14]
Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
[15]
Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118, Magdeburg, Germany.
[16]
German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
[17]
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
[18]
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
[19]
Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.
[20]
Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK.
[21]
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
[22]
German Center for Neurodegenerative Diseases (DZNE), Gehlsheimer Str. 20, 18147, Rostock, Germany.
[23]
Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany.
[24]
Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
[25]
Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.
[26]
Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany.
[27]
MR-Research in Neurosciences, Department of Cognitive Neurology, Georg-August-University, Goettingen, Germany.
[28]
Bernstein Center for Computational Neurosciences, Charité - Universitätsmedizin, Berlin, Germany.
[29]
Department for Biomedical Magnetic Resonance, University of Tübingen, 72076, Tübingen, Germany.
[30]
Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener Strasse 62, 50924, Cologne, Germany.
[31]
Department of Neurology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
[32]
Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
[33]
Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.
[34]
Division Translational Genomics of Neurodegenerative Diseases, Center for Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller-Strasse 27, 72076, Tübingen, Germany.
[35]
German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany. michael.heneka@uni.lu.
[36]
Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Venusberg-Campus 1, 53127, Bonn, Germany. michael.heneka@uni.lu.
[37]
Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7 avenue des Hauts Fourneaux, 4362, Esch-sur- Alzette, Luxembourg. michael.heneka@uni.lu.
[38]
主题词
人类(Humans);阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);脑(Brain);白细胞介素6(Interleukin-6);tau蛋白质类(tau Proteins)
DOI
10.1186/s13195-022-01118-0
PMID
36631909
发布时间
2023-02-15
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Alzheimer's research & therapy
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