Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction.

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第一作者： Gang,She

第一单位： Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an, 710061, Shaanxi, China.

作者： Gang,She ^[1] ; Jin-Chan,Du ^[1] ; Wei,Wu ^[1] ; Tian-Tian,Pu ^[1] ; Yu,Zhang ^[1] ; Ru-Yue,Bai ^[1] ; Yi,Zhang ^[1] ; Zheng-Da,Pang ^[1] ; Hui-Fang,Wang ^[2] ; Yu-Jie,Ren ^[2] ; Junichi,Sadoshima ^[3] ; Xiu-Ling,Deng ^[4] ; Xiao-Jun,Du ^[5]

作者单位： Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an, 710061, Shaanxi, China. ^[1] Department of Pathology, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated Guangren Hospital, Xi'an Jiaotong University Health Science Center, 21 Jiefang Road, Xi'an, 710005, Shaanxi, China. ^[2] Rutgers New Jersey Medical School, Department of Cell Biology and Molecular Medicine, New Jersey, United States of America. ^[3] Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an, 710061, Shaanxi, China.;Cardiovascular Research Centre, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an, 710061, Shaanxi, China. ^[4] Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an, 710061, Shaanxi, China.;Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia. ^[5]

关键词 Hippo pathway anti-cancer chemotherapy cardiomyopathy doxorubicin, verteporfin, cardiotoxicity mitochondrial damage