Lifelong exposure to high-altitude hypoxia in humans is associated with improved redox homeostasis and structural-functional adaptations of the neurovascular unit.

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第一作者： Benjamin S,Stacey

第一单位： Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.

作者： Benjamin S,Stacey ^[1] ; Ryan L,Hoiland ^[2] ; Hannah G,Caldwell ^[3] ; Connor A,Howe ^[3] ; Tyler,Vermeulen ^[3] ; Michael M,Tymko ^[4] ; Gustavo A,Vizcardo-Galindo ^[5] ; Daniella,Bermudez ^[5] ; Rómulo J,Figueroa-Mujíica ^[5] ; Christopher,Gasho ^[6] ; Edouard,Tuaillon ^[7] ; Christophe,Hirtz ^[8] ; Sylvain,Lehmann ^[8] ; Nicola,Marchi ^[9] ; Hayato,Tsukamoto ^[10] ; Francisco C,Villafuerte ^[5] ; Philip N,Ainslie ^[11] ; Damian M,Bailey ^[1]

作者单位： Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK. ^[1] Department of Anaesthesiology, Pharmacology and Therapeutics, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.;Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. ^[2] Centre for Heart, Lung and Vascular Health, University of British Columbia-Okanagan Campus, Kelowna, British Columbia, Canada. ^[3] Centre for Heart, Lung and Vascular Health, University of British Columbia-Okanagan Campus, Kelowna, British Columbia, Canada.;Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.;Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. ^[4] Laboratorio de Fisiología Comparada, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 31, Peru. ^[5] Division of Pulmonary and Critical Care, Loma Linda University School of Medicine, Loma Linda, CA, USA. ^[6] Department of Infectious Diseases, University of Montpellier, Montpellier, France. ^[7] LBPC-PPC, Université de Montpellier, IRMB CHU de Montpellier, INM INSERM, Montpellier, France. ^[8] Laboratory of Cerebrovascular and Glia Research, Department of Neuroscience, Institute of Functional Genomics, University of Montpellier, Montpellier, France. ^[9] Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan. ^[10] Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.;Centre for Heart, Lung and Vascular Health, University of British Columbia-Okanagan Campus, Kelowna, British Columbia, Canada. ^[11]

关键词 acclimatization cerebrovascular function cognition free radicals high altitude neurovascular unit