Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i>.

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第一作者： Andrej Emanuel,Cotman

第一单位： Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.

作者： Andrej Emanuel,Cotman ^[1] ; Martina,Durcik ^[1] ; Davide,Benedetto Tiz ^[1] ; Federica,Fulgheri ^[1] ; Daniela,Secci ^[1] ; Maša,Sterle ^[1] ; Štefan,Možina ^[1] ; Žiga,Skok ^[1] ; Nace,Zidar ^[1] ; Anamarija,Zega ^[1] ; Janez,Ilaš ^[1] ; Lucija,Peterlin Mašič ^[1] ; Tihomir,Tomašič ^[1] ; Diarmaid,Hughes ^[2] ; Douglas L,Huseby ^[2] ; Sha,Cao ^[2] ; Linnéa,Garoff ^[2] ; Talía,Berruga Fernández ^[2] ; Paraskevi,Giachou ^[2] ; Lisa,Crone ^[2] ; Ivailo,Simoff ^[3] ; Richard,Svensson ^[3] ; Bryndis,Birnir ^[4] ; Sergiy V,Korol ^[4] ; Zhe,Jin ^[4] ; Francisca,Vicente ^[5] ; Maria C,Ramos ^[5] ; Mercedes,de la Cruz ^[5] ; Björn,Glinghammar ^[6] ; Lena,Lenhammar ^[7] ; Sara R,Henderson ^[8] ; Julia E A,Mundy ^[8] ; Anthony,Maxwell ^[8] ; Clare E M,Stevenson ^[8] ; David M,Lawson ^[8] ; Guido V,Janssen ^[9] ; Geert Jan,Sterk ^[9] ; Danijel,Kikelj ^[1]

作者单位： Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. ^[1] Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden. ^[2] Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden. ^[3] Department of Medical Cell Biology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden. ^[4] Fundación MEDINA, Avenida del Conocimiento 34, Parque Tecnológico Ciencias de la Salud, 18016 Granada, Spain. ^[5] Department Chemical Process and Pharmaceutical Development, Unit Chemical and Pharmaceutical Safety, RISE Research Institutes of Sweden, 15136 Södertälje, Sweden. ^[6] Department of Medical Sciences, Uppsala University Hospital, 75185 Uppsala, Sweden. ^[7] Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K. ^[8] Medicinal Chemistry Division, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. ^[9]