An Investigation into the In Vitro Metabolic Stability of Aryl Sulfonyl Fluorides for their Application in Medicinal Chemistry and Radiochemistry.

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作者： Andrew T,King ^[1] ; Lidia,Matesic ^[2] ; Sinead T,Keaveney ^[1] ; Joanne F,Jamie ^[3]

作者单位： School of Natural Sciences, Wallumattagal Campus, Macquarie University, North Ryde, New South Wales 2109, Australia. ^[1] Australian Nuclear Science and Technology Organisation, New Illawarra Rd, Lucas Heights, New South Wales 2234, Australia. ^[2] School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales 2522, Australia. ^[3]

关键词 defluorination metabolic stability radiochemistry sulfonyl fluorides

主题词动物(Animals);大鼠(Rats);化学, 药物(Chemistry, Pharmaceutical);放射化学(Radiochemistry);氟化物(Fluorides);亚磺酸类(Sulfinic Acids)

DOI 10.1021/acs.molpharmaceut.2c00806

PMID 36638322

发布时间 2023-02-27

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