Features of tumor-microenvironment images predict targeted therapy survival benefit in patients with EGFR-mutant lung cancer.

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第一作者： Shidan,Wang

第一单位： Quantitative Biomedical Research Center, The Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

作者： Shidan,Wang ^[1] ; Ruichen,Rong ^[1] ; Donghan M,Yang ^[1] ; Junya,Fujimoto ^[2] ; Justin A,Bishop ^[3] ; Shirley,Yan ^[3] ; Ling,Cai ^[1] ; Carmen,Behrens ^[2] ; Lynne D,Berry ^[4] ; Clare,Wilhelm ^[5] ; Dara,Aisner ^[6] ; Lynette,Sholl ^[7] ; Bruce E,Johnson ^[8] ; David J,Kwiatkowski ^[9] ; Ignacio I,Wistuba ^[2] ; Paul A,Bunn ^[10] ; John,Minna ^[11] ; Guanghua,Xiao ^[12] ; Mark G,Kris ^[5] ; Yang,Xie ^[12]

作者单位： Quantitative Biomedical Research Center, The Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ^[1] Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ^[2] Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ^[3] Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. ^[4] Department of Thoracic Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. ^[5] Department of Pathology, University of Colorado, Denver, Colorado, USA. ^[6] Department of Pathology, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA. ^[7] Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. ^[8] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard University, Boston, Massachusetts, USA. ^[9] Division of Medical Oncology, School of Medicine, University of Colorado, Aurora, Colorado, USA. ^[10] Hamon Center for Therapeutic Oncology Research.;Departments of Internal Medicine and Pharmacology.;Simmons Comprehensive Cancer Center, and. ^[11] Quantitative Biomedical Research Center, The Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA.;Simmons Comprehensive Cancer Center, and.;Department of Bioinformatics, UT Southwestern Medical Center, Dallas, Texas, USA. ^[12]

关键词 Lung cancer Oncology

主题词人类(Humans);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);肿瘤微环境(Tumor Microenvironment);蛋白激酶抑制剂(Protein Kinase Inhibitors);肺肿瘤(Lung Neoplasms);抗药性, 肿瘤(Drug Resistance, Neoplasm);突变(Mutation)

DOI 10.1172/JCI160330

PMID 36647832

发布时间 2024-05-10

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