首页> Cell reports> Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.

Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.

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第一作者： Elizabeth L,Orth-He

第一单位： Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

作者： Elizabeth L,Orth-He ^[1] ; Hsin-Che,Huang ^[1] ; Sahana D,Rao ^[1] ; Qinghui,Wang ^[2] ; Qifeng,Chen ^[2] ; Claire M,O'Mara ^[2] ; Ashley J,Chui ^[1] ; Michelle,Saoi ^[3] ; Andrew R,Griswold ^[4] ; Abir,Bhattacharjee ^[2] ; Daniel P,Ball ^[2] ; Justin R,Cross ^[3] ; Daniel A,Bachovchin ^[5]

作者单位： Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[1] Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[2] Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[3] Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[4] Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: bachovcd@mskcc.org. ^[5]

关键词 CARD8 CP: Immunology DPP8/9 NLRP1 aminopeptidases inflammasomes peptides protein folding

医学主题词炎性体(Inflammasomes);衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);蛋白质折叠(Protein Folding);CARD信号接头蛋白质类(CARD Signaling Adaptor Proteins)

DOI 10.1016/j.celrep.2022.111965

PMID 36649711

发布时间 2023-03-28

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