A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety.

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作者： Yulu,Li ^[1] ; Juan,Liu ^[2] ; Wei,Chen ^[2] ; Wei,Wang ^[2] ; Fang,Yang ^[2] ; Ximing,Liu ^[2] ; Yao,Sheng ^[1] ; Kaixin,Du ^[2] ; Miaomiao,He ^[2] ; Xueyuan,Lyu ^[2] ; Huiyu,Li ^[2] ; Linlin,Zhao ^[3] ; Zhizhong,Wei ^[2] ; Fengchao,Wang ^[4] ; Sanduo,Zheng ^[2] ; Jianhua,Sui ^[4]

作者单位： Peking University-Tsinghua University-National Institute of Biological Sciences (PTN) Joint Graduate Program, School of Life Sciences, Peking University, Beijing, China. ^[1] National Institute of Biological Sciences (NIBS), Beijing, China. ^[2] Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. ^[3] PTN Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing, China. ^[4] Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. ^[5] National Institute of Biological Sciences (NIBS), Beijing, China. suijianhua@nibs.ac.cn. ^[6] Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. suijianhua@nibs.ac.cn. ^[7]

关键词 CD47 Fc effector function Side effects Solid tumor Therapeutic efficacy Tumor selectivity pH-dependent antibody