Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer.

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第一作者： Anne Mette G,Jensen

第一单位： Department of Biomedicine, Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, 8000 Denmark.

作者： Anne Mette G,Jensen ^[1] ; Yu,Kitago ^[2] ; Elnaz,Fazeli ^[1] ; Christian B,Vægter ^[1] ; Scott A,Small ^[3] ; Gregory A,Petsko ^[4] ; Olav M,Andersen ^[2]

作者单位： Department of Biomedicine, Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, 8000 Denmark. ^[1] Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115. ^[2] Department of Neurology, Columbia University, New York, NY 10032. ^[3] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY 10032. ^[4]

关键词 Alzheimer’s disease SORL1 dimerization minigene pathogenicity

主题词人类(Humans);阿尔茨海默病(Alzheimer Disease);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);二聚作用(Dimerization);LDL受体相关蛋白质类(LDL-Receptor Related Proteins);膜转运蛋白质类(Membrane Transport Proteins);蛋白质转运(Protein Transport)

DOI 10.1073/pnas.2212180120

PMID 36652482

发布时间 2023-07-19

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