Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency.

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作者： Ye-Eun,Jung ^[1] ; Kyeong Won,Lee ^[2] ; Jae Hyun,Cho ^[3] ; Da-Woon,Bae ^[1] ; Bo-Gyeong,Jeong ^[1] ; Yeon-Ju,Jung ^[1] ; Soo-Bong,Park ^[1] ; Young Jun,An ^[2] ; Kyungchan,Kim ^[3] ; Ga Seul,Lee ^[4] ; Lin-Woo,Kang ^[5] ; Jeong Hee,Moon ^[4] ; Jung-Hyun,Lee ^[2] ; Eun-Kyoung,Kim ^[6] ; Hyung-Soon,Yim ^[7] ; Sun-Shin,Cha ^[8]

作者单位： Department of Chemistry & Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea. ^[1] Marine Biotechnology Research Center, Korea Institute of Ocean Science and Technology, 385 Haeyang-Ro, Busan, 49111, Republic of Korea. ^[2] Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, Republic of Korea. ^[3] Disease Target Structure Research Center, Korea Research Institute Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea. ^[4] Department of Biological Sciences, Konkuk University, Seoul, 05029, Republic of Korea. ^[5] Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, Republic of Korea. ekkim@dgist.ac.kr. ^[6] Neurometabolomics Research Center, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, Republic of Korea. ekkim@dgist.ac.kr. ^[7] Marine Biotechnology Research Center, Korea Institute of Ocean Science and Technology, 385 Haeyang-Ro, Busan, 49111, Republic of Korea. yimh@kiost.ac.kr. ^[8] Department of Chemistry & Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea. chajung@ewha.ac.kr. ^[9]