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首页> Redox report : communications in free radical research> Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.

Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.

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作者： Hanem M,Rabah ^[1] ; Darin A,Mohamed ^[2] ; Reham A,Mariah ^[1] ; Sarah R,Abd El-Khalik ^[1] ; Haidy A,Khattab ^[3] ; Norhan A,AbuoHashish ^[4] ; Amal M,Abdelsattar ^[5] ; Mohamed A,Raslan ^[6] ; Eman E,Farghal ^[7] ; Amira K,Eltokhy ^[1]

作者单位： Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt. ^[1] Histopathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. ^[2] Medical Physiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. ^[3] Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. ^[4] Anatomy Department, Faculty of Medicine, Tanta University, Tanta, Egypt. ^[5] Gynecology and Obstetrics Department, Faculty of Medicine, Tanta University, Tanta, Egypt. ^[6] Clinical and Chemical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. ^[7]

关键词 PI3K/Akt pathway Polycystic ovary syndrome SeNPs insulin resistance metformin mitochondrial dysfunction obesity oxidative stress

主题词女(雌)性(Female);人类(Humans);大鼠(Rats);动物(Animals);多囊卵巢综合征(Polycystic Ovary Syndrome);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);胰岛素抗药性(Insulin Resistance);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);硒(Selenium);二甲双胍(Metformin);信号传导(Signal Transduction);氧化还原(Oxidation-Reduction);肥胖症(Obesity);纳米粒子(Nanoparticles);线粒体(Mitochondria);脂类(Lipids)

DOI 10.1080/13510002.2022.2160569

PMID 36661246

发布时间 2023-01-25

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Redox report : communications in free radical research

Redox report

2023年28卷1期

2160569页

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Redox report : communications in free radical research

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Redox report

2023年28卷1期

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