A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.

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第一作者： Benjamin G,Faber

第一单位： Musculoskeletal Research Unit, Translational Health Sciences, and Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK.

作者： Benjamin G,Faber ^[1] ; Monika,Frysz ^[1] ; April E,Hartley ^[2] ; Raja,Ebsim ^[3] ; Cindy G,Boer ^[4] ; Fiona R,Saunders ^[5] ; Jennifer S,Gregory ^[5] ; Richard M,Aspden ^[5] ; Nicholas C,Harvey ^[6] ; Lorraine,Southam ^[7] ; William,Giles ^[8] ; Christine L,Le Maitre ^[9] ; J Mark,Wilkinson ^[8] ; Joyce B J,van Meurs ^[10] ; Eleftheria,Zeggini ^[11] ; Timothy,Cootes ^[3] ; Claudia,Lindner ^[3] ; John P,Kemp ^[12] ; George,Davey Smith ^[2] ; Jonathan H,Tobias ^[1]

作者单位： Musculoskeletal Research Unit, Translational Health Sciences, and Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK. ^[1] Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK. ^[2] Division of Informatics, Imaging and Data Science, The University of Manchester, UK. ^[3] Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. ^[4] Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, UK. ^[5] Medical Research Council Lifecourse Epidemiology Centre, University of Southampton, UK, and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK. ^[6] Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. ^[7] Department of Oncology and Metabolism, The University of Sheffield, UK. ^[8] Biomolecular Sciences Research Centre, Sheffield Hallam University, UK. ^[9] Department of Internal Medicine and Department of Orthopaedics & Sports Medicine, Erasmus MC, Rotterdam, The Netherlands. ^[10] Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany, and TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Germany. ^[11] Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK, and The University of Queensland Diamantina Institute and Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia. ^[12]

主题词人类(Humans);老年人(Aged);骨关节炎, 髋(Osteoarthritis, Hip);全基因组关联研究(Genome-Wide Association Study);疾病遗传易感性(Genetic Predisposition to Disease);关节成形术, 置换, 髋(Arthroplasty, Replacement, Hip);因果律(Causality);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1002/art.42451

PMID 36662418

发布时间 2024-03-06

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Arthritis & rheumatology (Hoboken, N.J.)

2023年75卷6期

900-909页

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A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.

Arthritis & rheumatology (Hoboken, N.J.)

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A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.

Arthritis & rheumatology (Hoboken, N.J.)

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Arthritis & rheumatology (Hoboken, N.J.)

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