Population pharmacokinetics and pharmacogenetics of apatinib in adult cancer patients.

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第一作者： Xin-Mei,Yang

第一单位： Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, China.

作者： Xin-Mei,Yang ^[1] ; Pan-Pan,Ye ^[1] ; Xiao-Lin,Liu ^[2] ; Zi-Xuan,Guo ^[3] ; Min,Kan ^[4] ; Qian,Li ^[1] ; Lin-Lin,Song ^[1] ; Hong-Ying,Liu ^[1] ; Ke-Guang,Chen ^[1] ; Jin-Yi,Shi ^[1] ; Ye-Hui,Zhang ^[1] ; Ya,Li ^[1] ; Fu-Rong,Zhao ^[1] ; John,van den Anker ^[5] ; Yan,Li ^[6] ; Wei,Zhao ^[7]

作者单位： Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, China. ^[1] Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, China. ^[2] Department of Pharmacy, China - Japan Friendship Hospital, Beijing, China. ^[3] Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. ^[4] Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA. ^[5] Departments of Pediatrics, Pharmacology & Physiology, Genomics & Precision Medicine, George Washington University, School of Medicine and Health Sciences, Washington, DC, USA. ^[6] Department of Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Basel, Switzerland. ^[7]

关键词 CYP3A5 genotype apatinib population pharmacokinetics systemic cancer type