RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer.

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第一作者： Hong-Tao,Li

第一单位： Department of Urology, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.

作者： Hong-Tao,Li ^[1] ; H Josh,Jang ^[2] ; Krizia,Rohena-Rivera ^[3] ; Minmin,Liu ^[2] ; Hemant,Gujar ^[1] ; Justin,Kulchycki ^[2] ; Shuqing,Zhao ^[1] ; Sandrin,Billet ^[3] ; Xinyi,Zhou ^[1] ; Daniel J,Weisenberger ^[4] ; Inderbir,Gill ^[1] ; Peter A,Jones ^[5] ; Neil A,Bhowmick ^[6] ; Gangning,Liang ^[7]

作者单位： Department of Urology, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA. ^[1] Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. ^[2] Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. ^[3] Department of Biochemistry and Molecular Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA. ^[4] Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: peter.jones@vai.org. ^[5] Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. Electronic address: neil.bhowmick@cshs.org. ^[6] Department of Urology, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: gliang@usc.edu. ^[7]

关键词 CP: Cancer DNMT inhibitors RNA mis-splicing SETD2 ccRCC viral mimicry

主题词人类(Humans);组蛋白类(Histones);肾肿瘤(Kidney Neoplasms);癌, 肾细胞(Carcinoma, Renal Cell);染色质(Chromatin);RNA(RNA)

DOI 10.1016/j.celrep.2023.112016

PMID 36662621

发布时间 2023-03-28

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