首页> Journal of enzyme inhibition and medicinal chemistry> Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the <i>P</i>-glycoprotein expression levels.

Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the <i>P</i>-glycoprotein expression levels.

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第一作者： Lali M,Al-Harbi

第一单位： Chemistry Department, Faculty of Science, King Abdul-AzizUniversity, Jeddah, Saudi Arabia.

作者： Lali M,Al-Harbi ^[1] ; Eman A,Al-Harbi ^[2] ; Rawda M,Okasha ^[2] ; R A,El-Eisawy ^[3] ; Mohammed A A,El-Nassag ^[4] ; Hany M,Mohamed ^[5] ; Ahmed M,Fouda ^[6] ; Ahmed A,Elhenawy ^[7] ; Ahmed,Mora ^[4] ; Ahmed M,El-Agrody ^[4] ; Heba K A,El-Mawgoud ^[8]

作者单位： Chemistry Department, Faculty of Science, King Abdul-AzizUniversity, Jeddah, Saudi Arabia. ^[1] Chemistry Department, Faculty of Science, Taibah University, Medina, Saudi Arabia. ^[2] Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.;Chemistry Department, Faculty of Science and Art, Al-Baha University, Al-Baha, Saudi Arabia. ^[3] Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt. ^[4] Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.;Chemistry Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia. ^[5] Chemistry Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia. ^[6] Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.;Chemistry Department, Faculty of Science and Art, AlBaha University, Al Bahah, Saudi Arabia. ^[7] Chemistry Department, Faculty of Women for Arts, Science, and Education, Ain Shams University, Cairo, Egypt. ^[8]

关键词 1H-Benzo[f]chromenes MCF-7/ADR P-glycoprotein SAR Ultrasound synthesis antitumor activity cell cycle arrest western blot

医学主题词人类(Humans);抗肿瘤药(Antineoplastic Agents);苯吡喃类(Benzopyrans);多柔比星(Doxorubicin);抗药性, 肿瘤(Drug Resistance, Neoplasm);肿瘤(Neoplasms)

DOI 10.1080/14756366.2022.2155814

PMID 36662632

发布时间 2023-02-02

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