Peptides from the Sea Anemone <i>Metridium senile</i> with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors.

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作者： Igor E,Kasheverov ^[1] ; Yulia A,Logashina ^[1] ; Fedor D,Kornilov ^[2] ; Vladislav A,Lushpa ^[1] ; Ekaterina E,Maleeva ^[3] ; Yuliya V,Korolkova ^[1] ; Jinpeng,Yu ^[3] ; Xiaopeng,Zhu ^[1] ; Dongting,Zhangsun ^[1] ; Sulan,Luo ^[4] ; Klara,Stensvåg ^[4] ; Denis S,Kudryavtsev ^[4] ; Konstantin S,Mineev ^[4] ; Yaroslav A,Andreev ^[5]

作者单位： Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia. ^[1] Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya str. 8, bld. 2, 119991 Moscow, Russia. ^[2] Moscow Institute of Physics and Technology, Institutsky per., 9, 141700 Dolgoprudnyi, Russia. ^[3] Medical School, Guangxi University, Nanning 530004, China. ^[4] Faculty of Biosciences, Fisheries and Economics, Norwegian College of Fishery Science, UiT-The Arctic University of Norway, NO 9037 Tromsø, Norway. ^[5]

关键词 ICK fold peptides Metridium senile NMR structure electrophysiology nicotinic acetylcholine receptors radioligand assay sea anemone venom

主题词动物(Animals);大鼠(Rats);胱氨酸(Cystine);烟碱拮抗剂(Nicotinic Antagonists);肽类(Peptides);受体, 烟碱(Receptors, Nicotinic);海葵(Sea Anemones)

DOI 10.3390/toxins15010028

PMID 36668848

发布时间 2023-11-18

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