Synthesis and biological evaluation of novel aromatic amide derivatives as potential BCR-ABL inhibitors.

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作者： Xiujun,Wang ^[1] ; Zhou,Xu ^[1] ; Jing,Feng ^[1] ; Gang,Pan ^[1] ; Xingbei,He ^[1] ; Mingxiao,Lv ^[1] ; Huijie,Chen ^[1] ; Wentao,Jiang ^[2] ; Jing,Ji ^[3] ; Mingli,Yang ^[4]

作者单位： College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China. ^[1] College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China; Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang 222000, China. ^[2] College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China. Electronic address: jijing@jou.edu.cn. ^[3] Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang 222000, China. Electronic address: ymlwxj@126.com. ^[4]

关键词 Anti-tumor activity Apoptosis Aromatic amide derivatives BCR-ABL1 kinase inhibitor Cell-cycle Chronic myeloid leukemia

主题词人类(Humans);融合蛋白质类, bcr-abl(Fusion Proteins, bcr-abl);酰胺类(Amides);抗药性, 肿瘤(Drug Resistance, Neoplasm);蛋白激酶抑制剂(Protein Kinase Inhibitors);K562细胞(K562 Cells);细胞凋亡(Apoptosis)

DOI 10.1016/j.bmcl.2023.129144

PMID 36681201

发布时间 2023-03-10

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