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Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury.

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第一作者： Hyoung Kyu,Kim

第一单位： Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea.;Department of Health Sciences and Technology, Graduate School, Inje University, Busan, South Korea.

作者： Hyoung Kyu,Kim ^[1] ; Min,Kim ^[2] ; Jubert C,Marquez ^[1] ; Seung Hun,Jeong ^[2] ; Tae Hee,Ko ^[2] ; Yeon Hee,Noh ^[2] ; Pham Trong,Kha ^[2] ; Ha Min,Choi ^[2] ; Dong Hyun,Kim ^[3] ; Jong Tae,Kim ^[4] ; Young Il,Yang ^[4] ; Kyung Soo,Ko ^[1] ; Byoung Doo,Rhee ^[1] ; Larisa K,Shubina ^[5] ; Tatyana N,Makarieva ^[5] ; Dmitry Y,Yashunsky ^[6] ; Alexey G,Gerbst ^[6] ; Nikolay E,Nifantiev ^[6] ; Valentin A,Stonik ^[5] ; Jin,Han ^[7]

作者单位： Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea.;Department of Health Sciences and Technology, Graduate School, Inje University, Busan, South Korea. ^[1] Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea.;Department of Physiology, BK Plus Project Team, College of Medicine, Inje University, Busan, South Korea. ^[2] Department of Pharmacology and Pharmaco-Genomics Research Center, College of Medicine, Inje University, Busan, South Korea. ^[3] Paik Institute for Clinical Research, Inje University College of Medicine, Busan, South Korea. ^[4] G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok, Russia. ^[5] Laboratory of Glycoconjugate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia. ^[6] Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea.;Department of Health Sciences and Technology, Graduate School, Inje University, Busan, South Korea.;Department of Physiology, BK Plus Project Team, College of Medicine, Inje University, Busan, South Korea. ^[7]

关键词 ATP, adenosine triphosphate GSK-3, glycogen synthase kinase–3 GSK-3β inhibition I/R, ischemia/reperfusion MI, myocardial infarction NAD+, nicotinamide adenine dinucleotide NADH, nicotinamide adenine dinucleotide, reduced NPS A NPS A, neopetroside A Nqo1, NAD(P)H:quinone oxidoreductase 1 Nrf2, nuclear factor erythroid 2–related factor 2 OCR, oxygen consumption rate ischemia/reperfusion injury mPTP, mitochondrial permeability transition pore mTOR, mammalian target of rapamycin marine pyridine α-nucleoside mitochondria

DOI 10.1016/j.jacbts.2022.05.004

PMID 36687267

发布时间 2023-02-01

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JACC. Basic to translational science

2022年7卷11期

1102-1116页

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JACC. Basic to translational science

2022年7卷11期

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Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury.

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Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury.

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