Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis.

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第一作者： Gerdien,Mijnheer

第一单位： Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

作者： Gerdien,Mijnheer ^[1] ; Nila Hendrika,Servaas ^[1] ; Jing Yao,Leong ^[2] ; Arjan,Boltjes ^[1] ; Eric,Spierings ^[1] ; Phyllis,Chen ^[2] ; Liyun,Lai ^[2] ; Alessandra,Petrelli ^[1] ; Sebastiaan,Vastert ^[3] ; Rob J,de Boer ^[4] ; Salvatore,Albani ^[2] ; Aridaman,Pandit ^[1] ; Femke,van Wijk ^[1]

作者单位： Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. ^[1] Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, the Academia, Singapore, Singapore. ^[2] Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.;Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. ^[3] Theoretical Biology, Utrecht University, Utrecht, Netherlands. ^[4]

关键词 CyTOF human immunology inflammation juvenile idiopathic arthritis regulatory T cell t cell receptor tissue inflammation

主题词人类(Humans);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);炎症(Inflammation);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);克隆细胞(Clone Cells)

DOI 10.7554/eLife.79016

PMID 36688525

发布时间 2023-03-22

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准确一般字义偏差语意偏离译文作用小提交