Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers.

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作者： Jordi,Pfeifer Serrahima ^[1] ; Congcong,Zhang ^[2] ; Pranav,Oberoi ^[2] ; Malena,Bodden ^[1] ; Jasmin,Röder ^[3] ; Claudia,Arndt ^[4] ; Anja,Feldmann ^[4] ; Anne,Kiefer ^[1] ; Maren,Prüfer ^[1] ; Ines,Kühnel ^[1] ; Torsten,Tonn ^[5] ; Michael,Bachmann ^[6] ; Winfried S,Wels ^[7]

作者单位： Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Straße 42-44, 60596, Frankfurt, Germany. ^[1] Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Straße 42-44, 60596, Frankfurt, Germany.;Partner Site Frankfurt/Mainz, German Cancer Consortium (DKTK), Frankfurt, Germany.;German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[2] Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Straße 42-44, 60596, Frankfurt, Germany.;Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany. ^[3] Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany. ^[4] Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.;Partner Site Dresden, German Cancer Consortium (DKTK), Dresden, Germany.;Institute for Transfusion Medicine, German Red Cross Blood Donation Service North-East, Dresden, Germany. ^[5] Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.;Partner Site Dresden, German Cancer Consortium (DKTK), Dresden, Germany.;National Center for Tumor Diseases (NCT) and Tumor Immunology, University Cancer Center (UCC) Carl Gustav Carus, TU Dresden, Dresden, Germany. ^[6] Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Straße 42-44, 60596, Frankfurt, Germany. wels@gsh.uni-frankfurt.de.;Partner Site Frankfurt/Mainz, German Cancer Consortium (DKTK), Frankfurt, Germany. wels@gsh.uni-frankfurt.de.;German Cancer Research Center (DKFZ), Heidelberg, Germany. wels@gsh.uni-frankfurt.de.;Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany. wels@gsh.uni-frankfurt.de. ^[7]

关键词 Chimeric antigen receptor ErbB2 HER2 NK-92 Natural killer cells UniCAR

主题词人类(Humans);杀伤细胞, 天然(Killer Cells, Natural);肿瘤(Neoplasms);免疫疗法, 过继(Immunotherapy, Adoptive);抗原, 肿瘤(Antigens, Neoplasm);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1007/s00262-023-03374-x

PMID 36688995

发布时间 2024-09-28

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准确一般字义偏差语意偏离译文作用小提交