ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.

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作者： Žiga,Skok ^[1] ; Martina,Durcik ^[1] ; Živa,Zajec ^[1] ; Darja,Gramec Skledar ^[1] ; Krištof,Bozovičar ^[1] ; Anja,Pišlar ^[1] ; Tihomir,Tomašič ^[1] ; Anamarija,Zega ^[1] ; Lucija,Peterlin Mašič ^[1] ; Danijel,Kikelj ^[1] ; Nace,Zidar ^[1] ; Janez,Ilaš ^[2]

作者单位： University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia. ^[1] University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia. Electronic address: janez.ilas@ffa.uni-lj.si. ^[2]

关键词 ATP-competitive Anticancer Catalytic inhibitor Cytotoxic Human DNA topoisomerase II

主题词人类(Humans);抗肿瘤药(Antineoplastic Agents);拓扑异构酶II抑制剂(Topoisomerase II Inhibitors);DNA拓扑异构酶类, Ⅱ型(DNA Topoisomerases, Type II);腺苷三磷酸(Adenosine Triphosphate);抗原, 肿瘤(Antigens, Neoplasm)

DOI 10.1016/j.ejmech.2023.115116

PMID 36689894

发布时间 2023-02-23

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