Parkin coregulates glutathione metabolism in adult mammalian brain.

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第一作者： Daniel N,El Kodsi

第一单位： Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

作者： Daniel N,El Kodsi ^[1] ; Jacqueline M,Tokarew ^[2] ; Rajib,Sengupta ^[1] ; Nathalie A,Lengacher ^[2] ; Ajanta,Chatterji ^[3] ; Angela P,Nguyen ^[4] ; Heather,Boston ^[1] ; Qiubo,Jiang ^[2] ; Carina,Palmberg ^[1] ; Chantal,Pileggi ^[2] ; Chet E,Holterman ^[1] ; Bojan,Shutinoski ^[5] ; Juan,Li ^[1] ; Travis K,Fehr ^[1] ; Matthew J,LaVoie ^[3] ; Rajiv R,Ratan ^[6] ; Gary S,Shaw ^[7] ; Masashi,Takanashi ^[1] ; Nobutaka,Hattori ^[1] ; Christopher R,Kennedy ^[1] ; Mary-Ellen,Harper ^[2] ; Arne,Holmgren ^[8] ; Julianna J,Tomlinson ^[9] ; Michael G,Schlossmacher ^[10]

作者单位： Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada. ^[1] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. ^[2] Department of Biochemistry, Karolinska Institute, Stockholm, Sweden. ^[3] Amity Institute of Biotechnology, Amity University, Kolkata, West Bengal, India. ^[4] Snyder Institute, University of Calgary, Calgary, AB, Canada. ^[5] Department of Biochemistry, Microbiology and Immunology Faculty of Medicine, and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada. ^[6] Kidney Research Center, Ottawa Hospital Research Institute, Ottawa, ON, Canada. ^[7] Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA. ^[8] Burke Neurological Institute, Weill Cornell Medical School, White Plains, NY, USA. ^[9] Department of Biochemistry, University of Western Ontario, London, ON, Canada. ^[10] Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. ^[11] Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada. jtomlinson@ohri.ca. ^[12] University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada. jtomlinson@ohri.ca. ^[13] Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada. mschlossmacher@toh.ca. ^[14] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. mschlossmacher@toh.ca. ^[15] University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada. mschlossmacher@toh.ca. ^[16] Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada. mschlossmacher@toh.ca. ^[17]

关键词 Early-onset Parkinson disease Glutathione metabolism Mass spectrometry Parkin Posttranslational modification Prkn Redox stress Sod2

主题词成年人(Adult);小鼠(Mice);人类(Humans);动物(Animals);谷胱甘肽二硫化物(Glutathione Disulfide);谷胱甘肽(Glutathione);蛋白质类(Proteins);氧化还原(Oxidation-Reduction);氧化性应激(Oxidative Stress);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);抗氧化剂(Antioxidants);半胱氨酸(Cysteine);脑(Brain);巯基化合物(Sulfhydryl Compounds);哺乳动物(Mammals)

DOI 10.1186/s40478-022-01488-4

PMID 36691076

发布时间 2023-12-05

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Acta neuropathologica communications

2023年11卷1期

19页

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Parkin coregulates glutathione metabolism in adult mammalian brain.

Acta neuropathologica communications

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Parkin coregulates glutathione metabolism in adult mammalian brain.

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