Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer.

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第一作者： Joyeeta,Roy

第一单位： Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States.

作者： Joyeeta,Roy ^[1] ; Armita,Kyani ^[1] ; Maha,Hanafi ^[2] ; Yibin,Xu ^[1] ; John,Takyi-Williams ^[3] ; Duxin,Sun ^[3] ; Essam Eldin A,Osman ^[2] ; Nouri,Neamati ^[1]

作者单位： Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States. ^[1] Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States.;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. ^[2] Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States.;Pharmaceutical Sciences, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States. ^[3]

主题词人类(Humans);配体(Ligands);吡嗪酰胺(Pyrazinamide);铜(Copper);胰腺肿瘤(Pancreatic Neoplasms);受体, Σ(Receptors, sigma)

DOI 10.1021/acs.jmedchem.2c01769

PMID 36692906

发布时间 2024-01-02

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