Novel pentacyclic derivatives and benzylidenes of the progesterone series cause anti-estrogenic and antiproliferative effects and induce apoptosis in breast cancer cells.

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作者： Alexander M,Scherbakov ^[1] ; Svetlana K,Vorontsova ^[2] ; Alvina I,Khamidullina ^[3] ; Jasminka,Mrdjanovic ^[4] ; Olga E,Andreeva ^[5] ; Fedor B,Bogdanov ^[5] ; Diana I,Salnikova ^[6] ; Vladimir,Jurisic ^[5] ; Igor V,Zavarzin ^[7] ; Valerii Z,Shirinian ^[2]

作者单位： Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye shosse 24, 115522, Moscow, Russia. a.sherbakov@ronc.ru. ^[1] N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991, Moscow, Russia. ^[2] Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 34/5, 119334, Moscow, Russian Federation. ^[3] Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Put Dr Goldmana 4, 21204, Sremska Kamenica, Serbia. ^[4] Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye shosse 24, 115522, Moscow, Russia. ^[5] Faculty of Medicine, Moscow State University, Lomonosovsky prospect 27 bldg. 1, 119991, Moscow, Russia. ^[6] Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia. ^[7]

关键词 Antiestrogenic activity Benzylidenes Breast cancer Estrogen receptor α Pentacyclic steroids