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Low protease activity in B cell follicles promotes retention of intact antigens after immunization.

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第一作者： Aereas,Aung

第一单位： Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.

作者： Aereas,Aung ^[1] ; Ang,Cui ^[2] ; Laura,Maiorino ^[1] ; Ava P,Amini ^[3] ; Justin R,Gregory ^[1] ; Maurice,Bukenya ^[1] ; Yiming,Zhang ^[4] ; Heya,Lee ^[1] ; Christopher A,Cottrell ^[5] ; Duncan M,Morgan ^[6] ; Murillo,Silva ^[1] ; Heikyung,Suh ^[1] ; Jesse D,Kirkpatrick ^[7] ; Parastoo,Amlashi ^[1] ; Tanaka,Remba ^[1] ; Leah M,Froehle ^[8] ; Shuhao,Xiao ^[1] ; Wuhbet,Abraham ^[1] ; Josetta,Adams ^[1] ; J Christopher,Love ^[9] ; Phillip,Huyett ^[10] ; Douglas S,Kwon ^[8] ; Nir,Hacohen ^[11] ; William R,Schief ^[12] ; Sangeeta N,Bhatia ^[13] ; Darrell J,Irvine ^[14]

作者单位： Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA. ^[2] Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.;Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA.;Program in Biophysics, Harvard University, Boston, MA, USA.;Microsoft Research New England, Cambridge, MA, USA. ^[3] Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.;Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[4] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.;Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA. ^[5] Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.;Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[6] Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.;Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA. ^[7] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. ^[8] Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. ^[9] Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, USA. ^[10] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. ^[11] Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.;Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.;IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA. ^[12] Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA.;Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Wyss Institute at Harvard, Boston, MA, USA.;Howard Hughes Medical Institute, Cambridge, MA, USA. ^[13] Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.;Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.;Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.;Howard Hughes Medical Institute, Cambridge, MA, USA.;Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[14]