The Development and Characterization of a Highly Sensitive Mature TGFβ3 Assay to Evaluate Anti-TGFβ3 Target Engagement.

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作者： A Francesca,Setiadi ^[1] ; Gizette,Sperinde ^[1] ; Melissa,Cheu ^[1] ; Wei-Ching,Liang ^[2] ; WeiYu,Lin ^[2] ; Connie,Mahood ^[1] ; Saloumeh K,Fischer ^[3]

作者单位： BioAnalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA. ^[1] Antibody Engineering, Genentech, South San Francisco, CA, 94080, USA. ^[2] BioAnalytical Sciences, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA. fischer.sally@gene.com. ^[3]

关键词 anti-TGFβ3 biomarker assay monoclonal antibody pharmacodynamics target engagement

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);转化生长因子β3(Transforming Growth Factor beta3);灵长目(Primates)

DOI 10.1208/s12248-023-00785-7

PMID 36703086

发布时间 2023-02-22

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准确一般字义偏差语意偏离译文作用小提交