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Global hypomethylation in childhood asthma identified by genome-wide DNA-methylation sequencing preferentially affects enhancer regions.

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作者单位: Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. [1] Associated Member of the German Center for Lung Research, Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. [2] German Cancer Research Center (DKFZ), Division of Theoretical Bioinformatics and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany. [3] Health Data Science Unit, Heidelberg University Hospital, Heidelberg, Germany. [4] Department of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany. [5] Friedrich-Schiller-University Jena, Jena University Language & Information Engineering (JULIE) Lab, Jena, Germany. [6] Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Systems Biology and Bioinformatics Unit, Jena, Germany. [7] Division of Cancer Epigenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. [8] German Center for Lung Research (DZL), Heidelberg, Munich, Germany. [9] Children's Hospital, Municipal Hospital "St. Georg", Leipzig, Germany. [10] Dr. von Hauner Children's Hospital, Ludwig Maximilian University Munich, Munich, Germany. [11] Helmholtz Zentrum München-German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Neuherberg, Germany. [12] Martin Luther University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Halle (Saale), Germany. [13] Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland. [14] Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland. [15] Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, Vandoeuvre les Nancy, France. [16] UMR 6249 Chrono-Environment, Centre National de la Recherche Scientifique and University of Franche-Comté, Besançon, France. [17] EA3450 Development, Adaptation and Handicap, University of Lorraine, Nancy, France. [18] Children's Hospital, Schwarzach, Austria. [19] Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU, Munich, Germany. [20] Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [21] Department of Pediatrics, Research Institute, Marien-Hospital Wesel, Wesel, Germany. [22] Pediatric Outpatient Department, Bad Honnef, Germany. [23] Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany. [24]
DOI 10.1111/all.15658
PMID 36704932
发布时间 2023-06-22
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Allergy

Allergy

2023年78卷6期

1489-1506页

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