Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau<sub>181</sub> levels in Aβ + patients within the Alzheimer's disease clinical spectrum.

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作者： Edoardo Nicolò,Aiello ^[1] ; Federico,Verde ^[2] ; Federica,Solca ^[1] ; Ilaria,Milone ^[3] ; Eleonora,Giacopuzzi Grigoli ^[1] ; Antonella,Dubini ^[1] ; Antonia,Ratti ^[4] ; Roberta,Ferrucci ^[5] ; Erminio,Torresani ^[1] ; Alberto,Priori ^[6] ; Nicola,Ticozzi ^[7] ; Vincenzo,Silani ^[8] ; Barbara,Poletti ^[9]

作者单位： Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy. ^[1] PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. ^[2] Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milan, Italy. ^[3] Neurology Residency Program, Università Degli Studi Di Milano, Milan, Italy. ^[4] Department of Laboratory Medicine, Laboratory of Clinical Chemistry, IRCCS Istituto Auxologico Italiano, Milan, Italy. ^[5] Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy. ^[6] Aldo Ravelli Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, International Medical School, University of Milan, Milan, Italy. ^[7] ASST Santi Paolo E Carlo, San Paolo University Hospital, Milan, Italy. ^[8] IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy. ^[9] Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy. b.poletti@auxologico.it. ^[10]

关键词 Alzheimer’s disease Cerebrospinal fluid Mild cognitive impairment Semantic Tau Verbal fluency

主题词人类(Humans);阿尔茨海默病(Alzheimer Disease);语义学(Semantics);回顾性研究(Retrospective Studies);tau蛋白质类(tau Proteins);淀粉样β肽类(Amyloid beta-Peptides)

DOI 10.1007/s10072-023-06643-w

PMID 36705785

发布时间 2023-05-15

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准确一般字义偏差语意偏离译文作用小提交