Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade.

导出 OA

翻译打印收藏纠错

作者： Claire,Conche ^[1] ; Fabian,Finkelmeier ^[2] ; Marina,Pešić ^[1] ; Adele M,Nicolas ^[2] ; Tim W,Böttger ^[3] ; Kilian B,Kennel ^[1] ; Dominic,Denk ^[2] ; Fatih,Ceteci ^[1] ; Kathleen,Mohs ^[2] ; Esther,Engel ^[1] ; Özge,Canli ^[2] ; Yasamin,Dabiri ^[1] ; Kai-Henrik,Peiffer ^[2] ; Stefan,Zeuzem ^[1] ; Gabriela,Salinas ^[2] ; Thomas,Longerich ^[3] ; Huan,Yang ^[1] ; Florian R,Greten ^[2]

作者单位： Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany. ^[1] Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany. ^[2] Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Goethe University Frankfurt, Frankfurt/Main, Germany. ^[3] University Medical Center Göttingen (UMG), Institute of Human Genetics, NGS- Integrative Genomics Core Unit (NIG), Göttingen, Germany. ^[4] Institute of Pathology, UniversitätsKlinikum Heidelberg, Heidelberg, Germany. ^[5] Center for Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA. ^[6] Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany greten@gsh.uni-frankfurt.de. ^[7] German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[8]

关键词 adenocarcinoma cell death colorectal cancer immunotherapy liver

主题词小鼠(Mice);动物(Animals);癌, 肝细胞(Carcinoma, Hepatocellular);肝肿瘤(Liver Neoplasms);HMGB1蛋白质(HMGB1 Protein);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);肿瘤微环境(Tumor Microenvironment)

DOI 10.1136/gutjnl-2022-327909

PMID 36707233

发布时间 2023-08-15

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交