Structure of the Inmazeb cocktail and resistance to Ebola virus escape.

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第一作者： Vamseedhar,Rayaprolu

第一单位： La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

作者： Vamseedhar,Rayaprolu ^[1] ; Benjamin O,Fulton ^[2] ; Ashique,Rafique ^[2] ; Emilia,Arturo ^[1] ; Dewight,Williams ^[3] ; Chitra,Hariharan ^[1] ; Heather,Callaway ^[1] ; Amar,Parvate ^[1] ; Sharon L,Schendel ^[1] ; Diptiben,Parekh ^[1] ; Sean,Hui ^[1] ; Kelly,Shaffer ^[1] ; Kristen E,Pascal ^[2] ; Elzbieta,Wloga ^[2] ; Stephanie,Giordano ^[2] ; Nicole,Negron ^[2] ; Min,Ni ^[2] ; Richard,Copin ^[2] ; Gurinder S,Atwal ^[2] ; Matthew,Franklin ^[2] ; Ruth Mabel,Boytz ^[4] ; Callie,Donahue ^[4] ; Robert,Davey ^[4] ; Alina,Baum ^[2] ; Christos A,Kyratsous ^[5] ; Erica Ollmann,Saphire ^[6]

作者单位： La Jolla Institute for Immunology, La Jolla, CA 92037, USA. ^[1] Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA. ^[2] Eyring Materials Center, Arizona State University, Tempe, AZ 85281, USA. ^[3] Department of Microbiology, Boston University of Medicine and NEIDL, Boston University, Boston, MA 02118, USA. ^[4] Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA. Electronic address: christos.kyratsous@regeneron.com. ^[5] La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA. Electronic address: erica@lji.org. ^[6]

关键词 Ebola antiviral cocktail cryo-EM escape structure therapeutics

主题词人类(Humans);埃博拉病毒(Ebolavirus);出血热, 埃博拉(Hemorrhagic Fever, Ebola);抗体, 病毒(Antibodies, Viral);糖蛋白类(Glycoproteins);表位(Epitopes);抗体, 中和(Antibodies, Neutralizing)

DOI 10.1016/j.chom.2023.01.002

PMID 36708708

发布时间 2023-07-31

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