首页> Lancet (London, England)> Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial.

Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial.

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第一作者： Melinda J,Hamer

第一单位： Walter Reed Army Institute of Research, Silver Spring, MD, USA; Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

作者： Melinda J,Hamer ^[1] ; Katherine V,Houser ^[2] ; Amelia R,Hofstetter ^[3] ; Ana M,Ortega-Villa ^[4] ; Christine,Lee ^[5] ; Anne,Preston ^[5] ; Brooke,Augustine ^[5] ; Charla,Andrews ^[3] ; Galina V,Yamshchikov ^[3] ; Somia,Hickman ^[3] ; Steven,Schech ^[6] ; Jack N,Hutter ^[5] ; Paul T,Scott ^[5] ; Paige E,Waterman ^[5] ; Mihret F,Amare ^[6] ; Victoria,Kioko ^[6] ; Casey,Storme ^[6] ; Kayvon,Modjarrad ^[5] ; Melanie D,McCauley ^[6] ; Merlin L,Robb ^[6] ; Martin R,Gaudinski ^[3] ; Ingelise J,Gordon ^[3] ; LaSonji A,Holman ^[3] ; Alicia T,Widge ^[3] ; Larisa,Strom ^[3] ; Myra,Happe ^[3] ; Josephine H,Cox ^[3] ; Sandra,Vazquez ^[3] ; Daphne A,Stanley ^[3] ; Tamar,Murray ^[3] ; Caitlyn N M,Dulan ^[3] ; Ruth,Hunegnaw ^[3] ; Sandeep R,Narpala ^[3] ; Phillip A,Swanson ^[3] ; Manjula,Basappa ^[3] ; Jagada,Thillainathan ^[3] ; Marcelino,Padilla ^[3] ; Britta,Flach ^[3] ; Sarah,O'Connell ^[3] ; Olga,Trofymenko ^[3] ; Patricia,Morgan ^[3] ; Emily E,Coates ^[3] ; Jason G,Gall ^[3] ; Adrian B,McDermott ^[3] ; Richard A,Koup ^[3] ; John R,Mascola ^[3] ; Aurélie,Ploquin ^[3] ; Nancy J,Sullivan ^[3] ; Julie A,Ake ^[5] ; Julie E,Ledgerwood ^[3] ; RV 507 Study Team

作者单位： Walter Reed Army Institute of Research, Silver Spring, MD, USA; Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. ^[1] Vaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: katherine.houser@nih.gov. ^[2] Vaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[3] Biostatistics Research Branch, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[4] Walter Reed Army Institute of Research, Silver Spring, MD, USA. ^[5] Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA. ^[6]