换一批Efficient stabilization of therapeutic hepatitis B vaccine components by amino-acid formulation maintains its potential to break immune tolerance.
第一作者：
Julia,Sacherl
第一单位：
Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Munich, Germany.
作者：
关键词
AAV, adeno-associated virusALT, alanine aminotransferaseCHB, chronic hepatitis BCTC, controlled temperature chainCtrl, controlDLS, dynamic light scatteringHBcAgHBcAg, hepatitis B core antigenHBeAg, hepatitis B e antigenHBsAgHBsAg, hepatitis B surface antigenHeat-stable vaccineICS, intracellular cytokine stainingIFNα, interferon alphaMVAMVA, Modified Vaccinia virus AnkaraNAGE, native agarose gel electrophoresisRH, relative humidityRT, room temperatureSAA, stabilizing amino acidsSEC-HPLC, size exclusion-high performance liquid chromatographySPS?TCID50, median tissue culture infection doseTherVacBCtrl, non-lyophilizedWHO, World Health Organizationanti-HBc, hepatitis B core antibodiesanti-HBs, hepatitis B surface antibodiescccDNA, covalently closed circular DNAformulationhepatitis B virusheterologous prime/boost vaccinationlyophilizationnon-stressed, non-stabilized TherVacBstabilizationstabilizing amino acid-based formulationstabilizing excipients
DOI
10.1016/j.jhepr.2022.100603
PMID
36714793
发布时间
2023-02-02
- 浏览2
JHEP reports
2023年5卷2期
100603页
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