Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis.

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第一作者： Florian,Ruiz

第一单位： Laboratories of Neuroimmunology, Service of Neurology and Neuroscience Research Center, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

作者： Florian,Ruiz ^[1] ; Benjamin,Peter ^[1] ; Jessica,Rebeaud ^[1] ; Solenne,Vigne ^[1] ; Valentine,Bressoud ^[1] ; Martin,Roumain ^[2] ; Tania,Wyss ^[3] ; Yannick,Yersin ^[1] ; Ingrid,Wagner ^[4] ; Mario,Kreutzfeldt ^[4] ; Marisa,Pimentel Mendes ^[1] ; Camille,Kowalski ^[5] ; Gael,Boivin ^[6] ; Leonard,Roth ^[7] ; Markus,Schwaninger ^[8] ; Doron,Merkler ^[4] ; Giulio G,Muccioli ^[2] ; Stephanie,Hugues ^[5] ; Tatiana V,Petrova ^[9] ; Caroline,Pot ^[1]

作者单位： Laboratories of Neuroimmunology, Service of Neurology and Neuroscience Research Center, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. ^[1] Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, UCLouvain, Université Catholique de Louvain, Brussels, Belgium. ^[2] Department of Oncology, University of Lausanne and Ludwig Institute for Cancer Research, Lausanne, Switzerland.;SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland. ^[3] Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.;Division of Clinical Pathology, Diagnostic Department, University Hospitals of Geneva, Geneva, Switzerland. ^[4] Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland. ^[5] Radio-Oncology Laboratory, Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. ^[6] Department of Epidemiology and Health Systems, Centre for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. ^[7] Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Luebeck, Germany. ^[8] Department of Oncology, University of Lausanne and Ludwig Institute for Cancer Research, Lausanne, Switzerland. ^[9]

关键词 cholesterol-25-hydroxylase endothelial cells experimental autoimmune encephalomyelitis oxysterols polymorphonuclear myeloid-derived suppressor cells

主题词小鼠(Mice);动物(Animals);脑脊髓炎, 自身免疫性, 实验性(Encephalomyelitis, Autoimmune, Experimental);内皮细胞(Endothelial Cells);中枢神经系统(Central Nervous System);小鼠, 近交C57BL(Mice, Inbred C57BL)

DOI 10.15252/embr.202255328

PMID 36715148

发布时间 2023-03-22

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